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Abstract #1268

Tongue deformation during mandibular advancement, as determined using tagged-MRI, may help to predict mandibular advancement treatment outcome in Obstructive sleep apnoea.

Lauriane Jugé1,2, Fiona Knapman1, Peter Burke1,2, Elizabeth Brown1,3, Jane Butler1,2, Danny Eckert1,2, Jo Ngiam4, Kate Sutherland4,5, Peter Cistulli4,5, and Lynne Bilston1,6

1Neuroscience Research Australia, Sydney, Australia, 2School of Medical Sciences, University of New South Wales, Sydney, Australia, 3Prince of Wales Hospital, Sydney, Australia, 4Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia, 5Charles Perkins Centre, University of Sydney, Sydney, Australia, 6Prince of Wales Clinical School, University of New South Wales, Sydney, Australia

Tongue deformation during mandibular advancement, as characterised by tagged-MRI, may be helpful to predict mandibular advancement splint (MAS) therapy for obstructive sleep apnea (OSA). 68 OSA patients untreated underwent a MRI scan prior to trialling a MAS and treatment outcome was determined. Preliminary results identified 3 possible tongue deformations (en bloc, oropharyngeal and minimal/backward) with variable impact on the upper airway size. Over all participants, tongue deformation was not associated with treatment outcome, but among obese participants, “en bloc” tongue deformation was associated with positive treatment outcomes. This may also improve the understanding of the mechanisms underpinning MAS therapy effectiveness.

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