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Abstract #1267

Magnetic Resonance Imaging Based Assessment of High Fat Diet Induced Mitochondrial Dysfunction Mediated Impaired Lipid Oxidation in Brown Adipose Tissue: Novel Mechanistic Insights

Jadegoud Yaligar1, Rengaraj Anantharaj1, Giang Le Thi Thu 1, Ritu Chawla2, Sanjay Kumar Verma1, Venkatesh Gopalan1, Houchun H Hu3, Karthik Mallilankaraman2, and S. Sendhil Velan1

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2Department of Physiology, National University of Singapore, Singapore, Singapore, 3Department of Radiology, Nationwide Children’s Hospital, Columbus, OH, United States

Understanding the functional aspects of BAT under obese and overweight conditions is important to improve metabolic dysfunction. Mechanisms that regulate the quality of BAT are influenced by dietary lipids and plays a vital role in fat oxidation. Our imaging and molecular biology data suggests that lipid oxidative capacity of the mitochondria in iBAT is compromised with increased accumulation of lipids. High fat dietary feeding did not affect the mitochondrial content. However, the mitochondrial function was profoundly impaired. The novel finding in this study is the reduction in the activity of complex II in HFD fed rats leading to mitochondrial dysfunction.

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