The reliability of 1H-MRS MEGA-PRESS measurements of inhibitory neurotransmitter GABA in the human brain typically suffers from macromolecular (MM) contaminations of GABA resonances. In this work, we present a novel MM suppression approach, which relies on adiabatic inversion of the longitudinal magnetization of both metabolites and MMs prior to playing out the MEGA-PRESS editing scheme, which is applied after an inversion time delay (TI) corresponding to the zero-crossing of MM magnetization. As demonstrated in healthy subjects, this new approach ensures appropriate MM suppression and provides additional GABA signal gain compared to the commonly applied approach with symmetrical MM editing.
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