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Abstract #1276

Cross-vendor standardization of a 3 T MRS protocol with semi-LASER

Adam Berrington1,2, Dinesh K Deelchand3, James Joers3, Michal Považan1,2, Michael Schär1, Joseph Gillen1,2, Peter B Barker1,2, and Gülin Öz3

1Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Center for Magnetic Resonance Reseach, University of Minnesota, Minneapolis, MN, United States

Acceptance of 1H-MRS for clinical use is hindered by variability in methodology across platforms. Cross-vendor standardization is thus desirable for large-scale studies to be conducted. Here, we standardize a semi-LASER scheme (TE=30 ms) with identical pulses, inter-pulse durations and acquisition protocol in phantom and healthy volunteers on Philips and Siemens 3 T systems. The implemented method resulted in high quality spectra with matched SNR, linewidth and spectral patterns in phantom and similar estimated metabolite concentrations in vivo: between-subject CVs for NAA were (2.6-11.0)% and (3.3-10.2)% for Philips and Siemens, respectively. This method highlights the potential for pooling data across multiple sites.

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