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Abstract #1279

ISIS based Relaxation Enhanced MR spectroscopy (iRE-MRS) for downfield spectroscopy at short echo times

Sonia I. Goncalves1 and Noam Shemesh1

1Neuroplasticity and Neural Activity Lab, Champalimaud Foundation, Lisbon, Portugal

MRS is a versatile technique that allows for the non-invasive in-vivo exploration of tissue metabolism. In most MRS pulse sequences based on broadband excitation, the acquisition is preceded by water saturation pulses that suppress the water bulk signal and implicitly also exchangeable protons downfield of water. We introduce a new method for short-TE downfield MRS and show that it detects multiple peaks in-vivo that extend beyond 9 ppm.

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