Abstract #1280

Repeatability and reproducibility of GABA quantification using MEGA-PRESS in anterior cingulate cortex as a biomarker for depression

Daniel Alamidi¹, Jan Weis², Christine Nabuurs³, Mats Fredrikson^4,5, Andreas Frick^4,6, Fredrik Ahs^4,5, Jakub Kraus^5,7, Jonas Persson⁸, and Maarten Versluis³

¹Philips, Stockholm, Sweden, ²Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden, ³Philips, Best, Netherlands, ⁴Department of Psychology, Uppsala University, Uppsala, Sweden, ⁵Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Psychology, Stockholm University, Stockholm, Sweden, ⁷Centre for Neuroscience, Central European Institute of Technology, Masaryk University, Brno, Czech Republic, ⁸Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden

Proton MRS of the anterior cingulate cortex (ACC) is an attractive biomarker as it provides non-invasive methods to quantify GABA levels that are linked with several psychiatric disorders. This study validates a MEGA-PRESS sequence that combines phase cycling with real time frequency drift correction to measure GABA spectra in phantom and human brain. The GABA levels of the ACC were repeatable and reproducible at two different scanning sites. Consequently, the technique is appropriate for future longitudinal psychiatric studies.

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