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Abstract #1280

Repeatability and reproducibility of GABA quantification using MEGA-PRESS  in anterior cingulate cortex as a biomarker for depression

Daniel Alamidi1, Jan Weis2, Christine Nabuurs3, Mats Fredrikson4,5, Andreas Frick4,6, Fredrik Ahs4,5, Jakub Kraus5,7, Jonas Persson8, and Maarten Versluis3

1Philips, Stockholm, Sweden, 2Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden, 3Philips, Best, Netherlands, 4Department of Psychology, Uppsala University, Uppsala, Sweden, 5Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 6Department of Psychology, Stockholm University, Stockholm, Sweden, 7Centre for Neuroscience, Central European Institute of Technology, Masaryk University, Brno, Czech Republic, 8Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden

Proton MRS of the anterior cingulate cortex (ACC) is an attractive biomarker as it provides non-invasive methods to quantify GABA levels that are linked with several psychiatric disorders. This study validates a MEGA-PRESS sequence that combines phase cycling with real time frequency drift correction to measure GABA spectra in phantom and human brain. The GABA levels of the ACC were repeatable and reproducible at two different scanning sites. Consequently, the technique is appropriate for future longitudinal psychiatric studies.

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