Abstract #1281

Comparison of adiabatic and non-adiabatic inversion pulses for lipid suppression in human calf muscle

Andreas Masek¹, Alexander Gussew¹, Martin Krämer¹, and Jürgen R. Reichenbach^1,2,3,4

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ²Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany, ³Abbe School of Photonics, Friedrich Schiller University Jena, Jena, Germany, ⁴Center of Medical Optics and Photonics, Friedrich Schiller University Jena, Jena, Germany

Overlapping signal contributions originating from different metabolites with similar molecular structure is a common problem of in vivo ¹H-MR spectroscopy with magnetic field strengths of ≤ 3 T. One prominent example is the “contamination” of the resonances of lactate with fat signals in ¹H-MR muscle spectra. The goal of this work was to implement a MRS sequence with inversion recovery based adiabatic/ nonadiabatic lipid suppression and to test this approach in vivo in two different human calf muscles.

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