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Abstract #1286

Simultaneous MRSI of GABA and glutathione using HERMES spectral editing at 3T

Kimberly Chan1,2,3, Richard Edden2,3, Georg Oeltzschner2,3, Muhammad Saleh2,3, and Peter Barker2,3

1Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

HERMES with single-voxel PRESS localization has been used to simultaneously edit multiple compounds. It’s often desirable to measure spectra from multiple brain regions, using MR spectroscopic imaging (MRSI). This study examined the feasibility of HERMES editing of GABA and GSH with a PRESS-localized MRSI sequence at 3T, and compared it to conventional MEGA-edited MRSI acquisitions. It’s found that adding symmetrical lipid suppression pulses to HERMES allows the sequence to be used in vivo and has an editing efficiency equivalent to that of separate acquisitions of GABA and GSH using MEGA-PRESS MRSI without an increase in measurement variability relative to MEGA-PRESS.

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