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Abstract #1287

High resolution mapping of GABA+ and Glx using motion-corrected, spiral-accelerated, edited 1D-semiLASER MRSI in the human brain at 7T

Philipp Moser1,2, Bernhard Strasser3, Lukas Hingerl1, Michal Považan4,5, Gilbert Hangel1, Eva Heckova1, Borjan Gagoski6, Andre van der Kouwe7, Ovidiu C. Andronesi7, Siegfried Trattnig1,2, and Wolfgang Bogner1

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 4Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 6Fetal-Neonatal Neuroimaging; Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 7Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

In vivo detection of gamma-aminobutyric acid (GABA) and glutamate (Glu), both major neurotransmitters in the human brain, benefits from the higher sensitivity and SNR at ultra-high field (7T) compared to lower field strengths. However, strong B1+ inhomogeneities and chemical shift displacement errors, as well as subject motion and carrier frequency drifts can significantly impair the experiment. We preliminarily propose the first high resolution full-slice in vivo mapping of GABA+ at 7T. Combining spatial-spectral spiral encoding for MRSI acceleration with B1-insensitive adiabatic pulses and real-time motion correction allows unprecedented high resolution J-difference editing at 7T in comparably short scan time.

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