An optimized version of the five-dimensional (5D) echo-planar correlated spectroscopic sequence using an adiabatic full passage (AFP) RF pulse pair has been implemented on a 3T MRI/MRS scanner equipped with a 15-channel transmit/receive coil. The sequence was initially tested using a corn oil phantom. The calf muscle of twelve healthy subjects (age 27.5±3.1 years) and six diabetic type 2 subjects was studied (age 62.3±9.8 years). The AFP pulse pair enabled a sharper profile and minimal chemical shift misregistration. The localization of the volume of interest showed differential distribution of metabolites and lipids in human calf muscle and tibial marrow.
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