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Abstract #1295

Uncovering Long Range J-coupled Lipid Resonances in Human Calf In-Vivo: Pilot Findings Using Localized Two Dimensional Total Correlated Spectroscopy

Manoj K Sarma1, Andres Saucedo1, Christine H Darwin2, Cathy C Lee2,3, Ravinder R. Regatte4, and M. Albert Thomas1

1Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, United States, 4Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States

Based on the same principle of localized correlated spectroscopy (L-COSY) of coherence transfer during mixing period, total correlated spectroscopy (TOCSY) is a powerful technique that can provide correlations for both direct and long range coupled spins via relayed coherence transfer. Due to the SAR issue, the potential of TOCSY has not been fully exploited in-vivo and only few versions of TOCSY have been evaluated in brain. Here we have implemented a novel version of localized TOCSY technique for implementation in human calf muscle in-vivo, and compared results from three mixing strategies. Results are presented from a corn oil phantom, and in-vivo 2D spectra from 4 healthy volunteers and 1 diabetic patient obtained on 3T clinical platforms. We demonstrated that TOCSY can uncover the hidden relayed peaks, particularly that of IMCL/EMCL in calf muscle which can play an important role in better estimation of degree of unsaturation.

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