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Abstract #1296

In vivo detection of NAD+ in human calf muscle at 7T using 28-channel knee volume coil

Puneet Bagga1, Neil Wilson1, Catherine DeBrosse1, Hari Hariharan1, and Ravinder Reddy1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous molecule present in all cells and tissues of the body with an important role in the redox reactions and metabolism. Small changes in NAD+ levels may lead to oxidative stress and may be a cause for various disorders. NAD+ is usually be detected in vivo by 31P NMR spectroscopy. Recently, NAD+ measurement with 1H MRS in the human brain was demonstrated. In the present study, we show for the first time, in vivo single voxel localized 1H MRS detection of NAD+ from the human calf muscle at 7T.

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