Abstract #1297

Profiling lipid composition in whole breast tumours using two dimensional (2D) double quantum filtered (DQF) correlation spectroscopy (COSY) and multiple quantum coherence (MQC) magnetic resonance spectroscopy (MRS)

Sai Man Cheung¹, Ehab Husain^2,3, Yazan Masannat^3,4, Vasiliki Mallikourti¹, Steven D Heys^3,4, and Jiabao He¹

¹Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, ²Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, ³School of Medicine, University of Aberdeen, Aberdeen, United Kingdom, ⁴Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom

Changes in lipid composition, such as polyunsaturated fatty acids (PUFA), have found to be potential biomarker of breast cancer. It has been shown that PUFA has a role in breast cancer initiation. The relationship in human between lipid composition and breast tumour grading warrants urgent investigation, as a pathway towards improved treatment. Conventional MRS suffers from overlap of nearby lipid and water peaks, and is insufficient for lipid composition measurement. We conducted double quantum filtered (DQF) correlation spectroscopy (COSY) to resolve lipid composition from the whole breast tumour, and multiple quantum coherence (MQC) MRS for further close investigation of PUFA.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.