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Abstract #1299

Indirect Detection and Spin Amplification of Non-Proton MRS and MRI by Solvent Proton Signals

Zhao Li1 and Yung-Ya Lin1

1Chemistry and Biochemistry, UCLA, Los Angeles, CA, United States

A general indirect-detection and spin-amplification scheme has been developed to enhance the sensitivity of heteronuclear MRS and MRI based on dynamic instability of the solvent proton magnetization under collective feedback fields of radiation damping and the distant dipolar field. The heteronuclear solute spins are first detected by the solvent proton spins through various magnetization transfer mechanisms and serve as small “input” signals to perturb the solvent proton magnetization, which is prepared in an unstable state. The weakly detected signal is then amplified through subsequent nonlinear evolution of the solvent proton magnetization to achieve 10x SNR improvement for 13C MRS and MRI.

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