The total intrahepatic lipid (IHL) content can reliably be determined with 1H-MRS, but measuring lipid composition (saturated, mono- and poly-unsaturated fatty acids) is very challenging. At 3T the allylic peak is contaminated with the alpha-carbonyl methylene resonance, which hampers accurate measure of lipid composition. Recently, we developed a new approach to determine the lipid composition using prior knowledge to correct the signal intensity for alpha carbonyl group using methyl resonance. Here, we determined the in vivo reproducibility of our approach and robust quantification of lipid composition in a group of subjects with a wide range of total liver fat content.
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