Abstract #1300

Reproducibility of the measurement of hepatic lipid composition with 1H MRS at 3T

Pandichelvam Veeraiah^1,2, Kay H.M Roumans², Joachim E Wildberger¹, Patrick Schrauwen², Vera B Schrauwen-Hinderling^1,2, and Lucas Lindeboom^1,2

¹Department of Radiology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands, ²Department of Human Biology and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands

The total intrahepatic lipid (IHL) content can reliably be determined with ¹H-MRS, but measuring lipid composition (saturated, mono- and poly-unsaturated fatty acids) is very challenging. At 3T the allylic peak is contaminated with the alpha-carbonyl methylene resonance, which hampers accurate measure of lipid composition. Recently, we developed a new approach to determine the lipid composition using prior knowledge to correct the signal intensity for alpha carbonyl group using methyl resonance. Here, we determined the in vivo reproducibility of our approach and robust quantification of lipid composition in a group of subjects with a wide range of total liver fat content.

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