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Abstract #1301

Preliminary study of proton magnetic resonance spectroscopy with multi-echo-time for simultaneous quantification and T2 measurement of glutamate.

Chi-Hyeon Yoo1,2, Kyu-Ho Song1, Song-I Lim1,2, Dong-Choel Woo2, and Bo-Young Choe1

1Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, 2Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea

This study presents our preliminary concept of multi-echo-time (TE) in vivo proton magnetic resonance spectroscopy (1H MRS) for the simultaneous quantification and T2 measurement of the brain metabolites, particularly glutamate. The feasibility of the proposed method was verified by comparing metabolite concentrations to that of conventional short-TE, and T2 relaxation times to that of conventional T2 measurement. Although TE points must be further optimized, the multi-TE in vivo 1H MRS could be used to simultaneously investigate the changes of brain metabolism and microenvironments in a scan time comparable to that of the conventional method.

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