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Abstract #1302

Feasibility of Echo Time Optimization for Glutamate and Myoinositol Detection using TE-Averaged PRESS Spectral Editing Technique in Human Brain at 3T.

Gokce Hale Hatay1 and Esin Ozturk Isik1

1Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey

This study aims to investigate the feasibility of echo time (TE) optimization for TE-averaged PRESS for faster detection of glutamate (Glu) and myoinositol (mI) in human brain at 3T. Proton MR spectroscopic imaging (1H-MRSI) data of a brain phantom and a healthy volunteer were acquired at 3T using 10 different TEs, which were selected based on prior Monte Carlo simulation results. TE-averaged PRESS spectra were created with best TE combinations, and metabolites were quantified in MATLAB. Our results indicated that TE-averaged PRESS with upto 5 TE’s could reliably detect separate Glu and mI metabolites.

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