This study aims to investigate the feasibility of echo time (TE) optimization for TE-averaged PRESS for faster detection of glutamate (Glu) and myoinositol (mI) in human brain at 3T. Proton MR spectroscopic imaging (1H-MRSI) data of a brain phantom and a healthy volunteer were acquired at 3T using 10 different TEs, which were selected based on prior Monte Carlo simulation results. TE-averaged PRESS spectra were created with best TE combinations, and metabolites were quantified in MATLAB. Our results indicated that TE-averaged PRESS with upto 5 TE’s could reliably detect separate Glu and mI metabolites.
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