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Abstract #1303

1H-localised 13C DEPT measurement of glutamate and glutamine turnover in human frontal lobe using [1-13C]glucose infusion at 7T

Bernard Lanz1, Chen Chen1, Carolina Campanha Fernandes1, Liz Simpson2, Adriana Anton3, Mohammad Katshu4, Mohan Rathnaiah4, Andrew Peters1, Ian Macdonald2, Stephen Williams5, Bill Deakin3, Peter Liddle4, and Peter Gordon Morris1

1Sir Peter Mansfield Imaging Centre, The University of Nottingham, Nottingham, United Kingdom, 2School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, United Kingdom, 3Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 4Institute of Mental Health, The University of Nottingham, Nottingham, United Kingdom, 5Centre for Imaging Science, University of Manchester, Manchester, United Kingdom

Human 13C MRS has recently shown its further potential in understanding neurological disorders. In the field of schizophrenia, 1H MRS has been applied with findings of abnormal concentrations of glutamate ﴾Glu﴿ and glutamine ﴾Gln﴿ in anterior cingulate cortex ﴾ACC﴿. It is therefore of interest to measure glutamate metabolism with 13C MRS in this brain region to get deeper understanding of these changes. In the present study, we applied localized 13C MRS at 7T upon [1-13C]glucose infusion, using a 13C/1H volume coil and polarisation transfer (DEPT) to test the feasibility of measuring glutamate turnover in ACC.

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