Abstract #1303

1H-localised 13C DEPT measurement of glutamate and glutamine turnover in human frontal lobe using [1-13C]glucose infusion at 7T

Bernard Lanz¹, Chen Chen¹, Carolina Campanha Fernandes¹, Liz Simpson², Adriana Anton³, Mohammad Katshu⁴, Mohan Rathnaiah⁴, Andrew Peters¹, Ian Macdonald², Stephen Williams⁵, Bill Deakin³, Peter Liddle⁴, and Peter Gordon Morris¹

¹Sir Peter Mansfield Imaging Centre, The University of Nottingham, Nottingham, United Kingdom, ²School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, United Kingdom, ³Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, ⁴Institute of Mental Health, The University of Nottingham, Nottingham, United Kingdom, ⁵Centre for Imaging Science, University of Manchester, Manchester, United Kingdom

Human ¹³C MRS has recently shown its further potential in understanding neurological disorders. In the field of schizophrenia, ¹H MRS has been applied with findings of abnormal concentrations of glutamate ﴾Glu﴿ and glutamine ﴾Gln﴿ in anterior cingulate cortex ﴾ACC﴿. It is therefore of interest to measure glutamate metabolism with ¹³C MRS in this brain region to get deeper understanding of these changes. In the present study, we applied localized ¹³C MRS at 7T upon [1-¹³C]glucose infusion, using a ¹³C/¹H volume coil and polarisation transfer (DEPT) to test the feasibility of measuring glutamate turnover in ACC.

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