Radial echo planar spectroscopic imaging (EPSI) is an efficient method for imaging hyperpolarized (HP) substrates. However, symmetric data sampling between even/odd echo components can lead to ghost artifacts that can interfere with spectral undersampling strategies that enhance SNR. The purpose of this study was to optimize the acquisition and reconstruction of a symmetric radial EPSI sequence for dynamic HP [1-13C]-pyruvate imaging. In this work, we show that the generalized Fourier transform technique preserves spectral bandwidth, reduces ghost and aliasing artifacts, and improves SNR compared to alternative strategies that separately consider even and odd echo subsets.
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