Data acquisition for MRS and MRSI requires a stable scanner frequency during the relatively long scan time. However, gradient heating and subject motion during the scan result in drifts of the scanner frequency. The effects of frequency drifts include reduced SNR, broad linewidth, and errors in spatial encoding and metabolite quantification. We had recently proposed a new navigator approach: outer volume suppression (OVS)-localized navigator, to prospectively correct frequency drifts without introducing SNR losses, overcoming the shortcomings of previous PRESS-localized navigator. The purpose of this study is to validate the OVS-localized navigator approach through the comparison with non-localized navigator and the quantitative evaluations of spectral quality and metabolite concentrations in 10 healthy subjects.
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