Abstract #1315

On the exploitation of slow macromolecular diffusion for baseline estimation in MR spectroscopy using 2D simultaneous fitting

André Döring¹, Victor Adalid¹, Chris Boesch¹, and Roland Kreis¹

¹Depts. Radiology and Biomedical Research, University of Bern, Bern, Switzerland

The slow diffusivity of macromolecules was exploited in 2D signal modeling with FiTAID to estimate the macromolecular baseline in MRS of human brain. Two approaches were used for baseline modeling: (i) a predefined model derived from high-field and T₁-based baseline determination and (ii) a model-free description by equally spaced Voigt resonances. Inspection of fit residues and comparison with literature reveals that the second model is more appropriate.

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