J-difference-edited MR spectroscopy allows for the detection of several low-concentration compounds at 3T, but suffers from long acquisition times. Multiplexed editing experiments provide simultaneous detection of two or three metabolites by differentially modulating the spin systems of interest, and separating edited signals into distinct sum or difference spectra. For a novel multiplexed experiment (HERCULES), with simulated metabolite basis functions we demonstrate that simultaneously modeling the sum and difference spectra results in comparable metabolite levels with lower coefficients of variation, compared to separate modeling of the sum and difference spectra.
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