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Abstract #1316

Simultaneous modeling of sum and difference spectra improves quantitative outcomes for edited MRS

Daniel Luc Rimbault1, Georg Oeltzschner2,3, Ali Alhamud1,4, Ernesta Meintjes1,4, and Richard A. E. Edden2,3

1Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Cape Universities Body Imaging Centre (CUBIC-UCT), Cape Town, South Africa

J-difference-edited MR spectroscopy allows for the detection of several low-concentration compounds at 3T, but suffers from long acquisition times. Multiplexed editing experiments provide simultaneous detection of two or three metabolites by differentially modulating the spin systems of interest, and separating edited signals into distinct sum or difference spectra. For a novel multiplexed experiment (HERCULES), with simulated metabolite basis functions we demonstrate that simultaneously modeling the sum and difference spectra results in comparable metabolite levels with lower coefficients of variation, compared to separate modeling of the sum and difference spectra.

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