Quantitation of MRSI data using water-scaling requires correction of the water signal for relaxation and CSF partial volume effects. We demonstrate the use of a rapid MRF sequence to characterize the water signal used to quantify MRS data, which we call WAter-scaling Quantification using MRF (WAQ-MRF) scan. WAQ-MRF provides subject-specific corrections of partial volume and relaxation effects for water-scaled data. By adding a one minute scan to a standard MRSI acquisition it is possible to eliminate the need for assuming literature values of relaxation and proton density to correct the water signal.
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