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Abstract #1324

Spectral Quantification for Multiple-TE Spectroscopy Using Spectral Priors and Measured Lineshape Distortion Function

Fan Lam1, Yudu Li1,2, and Zhi-Pei Liang1,2

1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

This work presents a new method for quantifying multiple-TE/two-dimensional spectroscopy data, characterized by the use of spectral priors obtained by quantum mechanical simulations and an experimentally measured lineshape distortion function derived from a set of multi-TE water spectroscopic data. Results from in vivo J-resolved spectroscopy data demonstrated the excellent fitting produced by the proposed method, and improved robustness over a standard parametric-model-based method. With further developments, such as extensions to different sequences and Cramer-Rao bound analysis, the proposed method should prove useful for a range of 2D spectroscopy experiments.

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