Metabolic profiles of oncogenically transformed neural progenitor cells (NPCs) derived from 3 and 12 month old mice were evaluated using one dimensional 1H NMR spectroscopy. Principal component analysis revealed two distinct clusters which corresponded to the differently-aged NPCs. Metabolites identified in these cell lines were similar but differed in their relative abundance. The 3 month NPCs were characterised by high lipid CH2, creatine and choline. The metabolic signature of 12 month NPCs featured high levels of taurine, myo-inositol and branched-chain amino acids. This data suggests alterations in metabolic phenotype of aged NPCs which may arise from differences in enzymatic capacity.
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