Abstract #1338

Gene Expression Profiling to Understand the 1H MRS Characterization of the VEGF Metabolic Secretome from a Triple Negative Human Breast Cancer Xenograft

Santosh Kumar Bharti¹, Balaji Kirshnamachary¹, Louis Dore-Savard², Brett Stark¹, Aleksander S. Popel³, and Zaver M Bhujwalla^1,4

¹Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ²McGill University Health Centre and RI-MUHC, Montreal, QC, Canada, ³Systems Biology Laboratory, Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ⁴Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

Vascular endothelial growth factor (VEGF A) is a potent regulator of angiogenesis, invasion, and metastasis, especially in breast cancer. Secreted VEGF that forms a part of the interstitial milieu along with other metabolites shapes the microenvironment. Here, using 1H MR spectroscopy and microarray, we have characterized the metabolic and gene signature of the tumor tissue derived from MDA-MB-231 cells that stably overexpressed VEGF gene. Metabolic changes supported by gene array data provide new insight into the role played by VEGF in breast cancer progression

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.