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Abstract #1339

1H MRS Reveals Major Changes in Brain Metabolites Induced by Human Pancreatic Cancer Xenografts

Santosh Kumar Bharti1, Paul T Winnard Jr.1, Yelena Mironchik1, Marie-France Penet1, Anirban Maitra2, and Zaver M Bhujwalla1,3

1Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 3Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

Our ongoing efforts are focused on understanding systemic metabolic changes that occur during cancer-induced cachexia using human pancreatic ductal adenocarcinoma (PDAC) xenografts, since the syndrome occurs with the highest frequency and severity in PDAC. We used 1H MRS to analyze brain metabolite levels in mice with and without cachexia inducing human PDAC xenografts. Spectra revealed depletion of several metabolites, including neurotransmitters, in cachectic mice. These findings provide new insights into disruption of brain metabolism that may compromise central nervous system (CNS) function. Identifying alterations of brain metabolism may provide novel interventions to prevent or reduce CNS injury and cachexia.

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