Abstract #1343

Comparing the Reproducibility of Commonly Used Magnetic Resonance Spectroscopy Techniques to Quantify Cerebral Glutathione at 3 T

Andrea Wijtenburg¹, Jamie Near², Stephanie Korenic¹, Frank Gaston¹, Hongji Chen¹, Mark Mikkelsen^3,4, Robert McMahon¹, Peter Kochunov¹, Elliot Hong¹, and Laura Rowland^1,5

¹Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States, ²Centre d’Imagerie Cérébrale, Douglas Mental Health Institute, Montreal, QC, Canada, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cerebral glutathione (GSH), a marker of oxidative stress processes, has been quantified in neurodegenerative diseases and psychiatric disorders using proton magnetic resonance spectroscopy. However, no studies to date have compared the reproducibility of the most commonly used magnetic resonance spectroscopy techniques for GSH quantification. Here, we scanned ten healthy adults twice and acquired spectroscopic data using PRESS, PR-STEAM, SPECIAL, and MEGA-PRESS at 3 Tesla. We assess reproducibility via mean coefficients of variation (CV) and mean absolute difference (AD).

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