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Abstract #1348

[Asp], [Glu] and [NAA] changes following traumatic brain injury revealed by J-edited 1H MRS.

Petr Menshchikov1,2, Natalia Semenova1,2,3, Andrei Manzhurtsev2,3, Maxim Ublinskii2,3, Ilya Melnikov2, and Tolib Akhadov2

1Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, 2Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 3Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation

For the first time new method based on MEGA-PRESS pulse sequence for simultaneous aspartate (Asp), glutamate (Glu) and N acetyl aspartate (NAA) cerebral in vivo concentrations quantification were used for monitoring important metabolic changes after severe traumatic brain injury. Revealed Glutamate and Aspartate decrease is associated with excititoxicity (rapidly release of Glu and Asp from vesicles). In addition, Asp reduction might result from reduced availability of Glu.[NAA], marker of neuronal activity, reduction may be associated with synthesis disruption due to reduction of major NAA precussor (Asp).

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