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Abstract #1349

Magnetization transfer among non-aqueous species and between them and water in spinal cord

Uzi Eliav1, Peter J. Basser2, and Gil Navon1

1School of Chemistry, Tel Aviv University, Tel Aviv, Israel, 2SQITS/NICHD, NIH, Bethesda, MD, United States

Previous publications demonstrated that the intensity of white matter (WM) images of spinal cord stem from aqueous and non-aqueous protons (having a peak at 3.5ppm). The peak of the non-aqueous protons was analyzed to be a superimposition of signals with a distribution of T2* (10-1000μs). Questions unanswered by these studies are whether the peaks with short and long T2* exchange magnetization among themselves, and whether they transfer magnetization (MT) to water. In the present publication these questions are addressed by combining double quantum filtering with magnetization transfer. The results demonstrate exchange between non-aqueous species and between them and water.

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