Meeting Banner
Abstract #1352

Characterizing altered glucose and glutamine metabolism in castration-resistant prostate cancer using high-resolution NMR

Jinny Sun1, Renuka Sriram2, Robert Bok2, Romelyn Delos Santos2, Mark Van Criekinge2, Daniel Vigneron2, and John Kurhanewicz2

1UC Berkeley – UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California, San Fracisco, San Francisco, CA, United States

This study demonstrates significant increases in flux through aerobic glycolysis, oxidative phosphorylation, and glutaminolysis with development of therapeutic resistance to androgen deprivation therapy using patient-derived cell lines and a transgenic murine model. Based on these metabolic differences between androgen-sensitive and insensitive prostate cancer, a combination of hyperpolarized [1-13C]pyruvate, [2-13C]pyruvate and [5-13C]glutamine can be used to noninvasively predict therapeutic resistance in future patient studies using HP 13C MRI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here