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Abstract #1353

Increase in Glutamate concentration during motor activation measured using functional Magnetic Resonance Spectroscopy (fMRS) at 3T.

Osnat Volovyk1 and Assaf Tal1

1Chemical Physics, Weizmann Institute of Science, Rehovot, Israel

In the presented study we've demonstrated that small changes in Glutamate concentration associated with performing simple motor task can be reliably detected with 3T system using functional 1H MR spectroscopy. Comparison between two differently timed paradigms for motor activation revealed a clear preference for longer-block designs. This suggests that motor activity-induced changes in Glutamate concentration are of minutes-long time-scale.

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