For a better understanding of metabolic processes underlying neurovascular mechanisms, fMRS represents a suitable technique. The combination of fMRS and optogenetics (O-fMRS) should allow targeting the metabolism of specific cell populations during their activation. Our study aims at developing O-fMRS methodology in rat to provide further insight into brain energetics during activation. Here we establish a comparison between O-fMRS and sensory-fMRS in the rat forepaw cortex to investigate whether energetic demands are similar.
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