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Abstract #1361

Opto-functional Magnetic Resonance Spectroscopy (O-fMRS): investigating brain energetics under optogenetic and sensory stimulation

Nathalie Just1 and Cornelius Faber1

1AG Experimentelle Magnetische Kernresonanz Translational Research Imaging Center (TRIC) Institut für, University Hospital Münster, Germany, Münster, Germany

For a better understanding of metabolic processes underlying neurovascular mechanisms, fMRS represents a suitable technique. The combination of fMRS and optogenetics (O-fMRS) should allow targeting the metabolism of specific cell populations during their activation. Our study aims at developing O-fMRS methodology in rat to provide further insight into brain energetics during activation. Here we establish a comparison between O-fMRS and sensory-fMRS in the rat forepaw cortex to investigate whether energetic demands are similar.

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