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Abstract #1362

Comparison of in vivo MRS and ex vivo HR-MAS MRS for assessment of metabolite content in the GOT1 small intestine neuroendocrine tumour model

Mikael Montelius1, Johan Spetz2, Diana Bernin3, Oscar Jalnefjord1,4, Maria Ljungberg1,4, and Eva Forssell-Aronsson1,4

1Dept. of Radiation Physics, University of Gothenburg, Gothenburg, Sweden, 2University of Gothenburg, Gothenburg, Sweden, 3Swedish NMR Center, University of Gothenburg, Gothenburg, Sweden, 4Dept. of medical physics and biomedical engineering, Sahlgrenska University hospital, Gothenburg, Sweden

In vivo characterisation of tumour metabolism using MRS would facilitate tumour therapy response assessment, but in vivo conditions may obscure the metabolic information acquired. In this study we investigate the information contained in in vivo MRS spectra of a neuroendocrine tumour model by correlating it to ex vivo HR-MAS MRS on excised tumour samples. Effects of post-mortem tissue degradation and tumour sample site on in vivo–ex vivo correlations are evaluated, and interpretation of in vivo data is discussed.

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