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Abstract #1363

A neuroimaging study of the effects of early vs. late anti-inflammatory treatment in a rodent model of Alzheimer’s disease

Caitlin Fowler1, Dan Madularu2, John Breitner3, and Jamie Near3

1Engineering, McGill University, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada, 3Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no effective treatments or known biomarkers for definitive diagnosis, substantiating the need for early detection of AD and early intervention. This project employs Magnetic Resonance Spectroscopy (MRS) to measure changes in neurometabolites as compared to behavioural measures of cognitive function, in a transgenic rat model of AD under treatment conditions. Preliminary results suggest that changes in metabolite levels are present before the onset of cognitive impairment, and between treatment and control groups, with some of these changes being sexually dimorphic.

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