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Abstract #1364

Longitudinal follow-up of brain metabolism in rat models of progressive Parkinson's disease using Magnetic Resonance Spectroscopy Imaging.

Carine Chassain1, Christophe Melon2, Guilhem Pages3, Yann Le Fur4, Pascal Salin2, Lydia Kerkerian-Le Goff2, and Franck Durif5,6

1MRI department, CHU Clermont-Ferrand, Clermont-Ferrand, France, 2IBDM, UMR 7288 CNRS / Aix-Marseille Université, Marseille, France, 3AgroResonance-UR370 QuaPA, Saint Genes Champanelle, France, 4Centre de Résonance Magnétique Biologique et Médicale UMR 7339 CNRS / Aix-Marseille Université, Marseille, France, 5Neurology department, CHU Clermont-Ferrand, Clermont-Ferrand, France, 66Université Clermont Auvergne (UCA), EA7280 NPSY-Sydo, Clermont-Ferrand, France

The development of animal models that reproduce the selective and progressive loss of nigral dopamine neurons characterizing Parkinson’s disease has opened new possibilities to study the disease evolution. Here magnetic resonance spectroscopy imaging was used to follow up the distributions of metabolites in key basal ganglia components in two rat models of progressive parkinsonism at three time points over a period of 120 days following injury. First results on overtime changes in NAA and glutamate repartition will be presented. Completion of this project may provide novel insights onto the pathological alterations associated with the progression of the neurodegenerative process.

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