Abstract #1365

Metabolic Consequences in the Heart and Skeletal Muscle of Human Pancreatic Cancer Xenograft Growth

Santosh Kumar Bharti¹, Paul T Winnard Jr.¹, Yelena Mironchik¹, Marie-France Penet¹, and Zaver M Bhujwalla^1,2

¹Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ²Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

To understand the metabolic events that occur during cancer-induced cachexia, here we analyzed the effects of human pancreatic cancer xenografts on heart and skeletal muscle metabolites using 1 H MRS. Studies were performed with cachexia-inducing Pa04C and non-cachexia inducing Panc1 human pancreatic cancer xenografts, since cachexia occurs most frequently in pancreatic cancer. 1H MR spectra identified differences in heart and skeletal muscle metabolites of cachectic and non-cachectic mice, as well as between normal mice and cachectic as well as non-cachectic mice. Our data highlight the systemic metabolic changes that occur with tumor growth and provide new insights in cancer-induced cachexia.

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