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Abstract #1385

The novel and quantitative MRI technique: Q-space imaging for evaluating intervertebral disc degeneration: basic and clinical study.

Daisuke Nakashima1, Nobuyuki Fujita2, Junichi Hata3,4, Takeo Nagura2, Kanehiro Fujiyoshi5, Hideyuki Okano3, Masahiro Jinzaki2, Morio Matsumoto2, and Masaya Nakamura2

1Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, 2Keio University School of Medicine, Tokyo, Japan, 3Central Institute for Experimental Animals, Kawasaki, Japan, 4Department of Physiology, Keio University School of Medicine, Tokyo, Japan, 5Murayama Medical Center, Tokyo, Japan

The conventional qualitative classification of intervertebral disc (IVD) degeneration: Pfirrmann classification on T2 weighted imaging does not have the enough sensitivity for the evaluation of IVD degeneration. In the present study, probability at zero displacement obtained from Q-space imaging (QSI) has a high sensitivity of IVD degeneration in both basic and clinical study compared with the conventional method: T2 mapping. In particular, probability at zero displacement made it possible to observe the effect of the regenerative drug: N-Acetyl Cystaine on IVD degeneration which could not be observed by using T2 mapping. Probability at zero displacement obtained from QSI has the possibility to be a novel biomarker of IVD degeneration.

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