Abstract #1385

The novel and quantitative MRI technique: Q-space imaging for evaluating intervertebral disc degeneration: basic and clinical study.

Daisuke Nakashima¹, Nobuyuki Fujita², Junichi Hata^3,4, Takeo Nagura², Kanehiro Fujiyoshi⁵, Hideyuki Okano³, Masahiro Jinzaki², Morio Matsumoto², and Masaya Nakamura²

¹Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, ²Keio University School of Medicine, Tokyo, Japan, ³Central Institute for Experimental Animals, Kawasaki, Japan, ⁴Department of Physiology, Keio University School of Medicine, Tokyo, Japan, ⁵Murayama Medical Center, Tokyo, Japan

The conventional qualitative classification of intervertebral disc (IVD) degeneration: Pfirrmann classification on T2 weighted imaging does not have the enough sensitivity for the evaluation of IVD degeneration. In the present study, probability at zero displacement obtained from Q-space imaging (QSI) has a high sensitivity of IVD degeneration in both basic and clinical study compared with the conventional method: T2 mapping. In particular, probability at zero displacement made it possible to observe the effect of the regenerative drug: N-Acetyl Cystaine on IVD degeneration which could not be observed by using T2 mapping. Probability at zero displacement obtained from QSI has the possibility to be a novel biomarker of IVD degeneration.

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