Abstract #1388

Analysis of Knee Cartilage using Magnetization Transfer and Multi-exponential T2* Fitting

Sooyeon Ji¹, Se-Hong Oh², Young-Han Lee³, Dongmyung Shin¹, Doohee Lee¹, Taehyun Hwang¹, Woojin Jung¹, Hyeong-Geol Shin¹, and Jongho Lee¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea, ²Department of Biomedical Engineering, Hankuk University of Foreign Studies, Seoul, Republic of Korea, ³Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of Korea

In this study, we explored the combined use of magnetization transfer (MT) weighting and bi-exponential T₂* fitting as a potential tool to analyze the composition and microscopic geometry of the knee cartilage. The analysis results of deep cartilage areas showed that the MT ratio of the short T₂* component had significantly larger values than that of the long T₂* component. This observation may be explained by the geometry of collagen fibrils and proteoglycans.

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