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Abstract #1393

Low-field MRI of osteoarthritis in humans: correlations between load-dependent cartilage properties and relaxation parameters

Erik Roessler1, Carlos Mattea1, Miika Nieminen2, Sakari Karhula2, Simo Saarakkala2, and Siegfried Stapf1

1Ilmenau University of Technology, Ilmenau, Germany, 2University of Oulu, Oulu, Finland

At low magnetic fields, T1 variation within cartilage is a robust parameter that is employed to quantify the layered structure in the tissue and is sensitive to factors such as enzymatic degradation, external load, and diseases such as osteoarthritis. Variable-field relaxometry provides access to the content and local order of glycosaminoglycans and collagen via proton-nitrogen quadrupolar dips. In this study on 20 human cartilage samples, load-dependent low-field and variable-field techniques were combined for the first time to correlate NMR parameters with the severity of osteoarthritis.

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