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Abstract #1392

Quantitative DCE-MRI perfusion imaging of the subchondral bone in knee osteoarthritis

Bas A. de Vries1, Joost Verschueren1, Dirk H.J. Poot2, Gabriel P. Krestin1, and Edwin H.G. Oei1

1Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, 2Medical Informatics, Erasmus MC, Rotterdam, Netherlands

Changes in subchondral bone in knee osteoarthritis could be a marker of altered fluid dynamics. Perfusion can be visualized and quantified with MRI using dynamic contrast enhanced MRI (DCE-MRI). Using quantitative analysis of DCE-MRI, we compared perfusion in the affected compartment with the non-affected compartment in patients with unicompartmental knee osteoarthritis. We also evaluated the perfusion in subchondral bone marrow lesions (BMLs). Perfusion of the subchondral bone measured with DCE-MRI is not significantly different between the affected and non-affected compartment. Subchondral BMLs are significantly associated with increased perfusion parameters compared to subchondral bone regions without BMLs.

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