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Abstract #1391

Macromolecular fraction from magnetization transfer ultrashort echo time (MT-UTE) modeling proportionally correlates with applied mechanical load on the cadaveric knee joint

Saeed Jerban1, Yajun Ma 1, Wei Zhao1, Michael Carl2, Eric Y Chang1,3, and Jiang Du1

1Radiology, University of California, San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Ultrashort echo time (UTE) MRI is able to assess long T2 tissues such as articular cartilage (AC) and short T2 tissues such as meniscus. Early stage of osteoarthritis is hypothesized to affect the mechanical properties of AC, sooner and quicker than its morphology. This study focused on the application of UTE imaging, including UTE magnetization transfer (UTE-MT) modelling, adiabatic T1r, T1 and T2* measurements in cadaveric human knee joints subject to sequential mechanical loading. Compression load application resulted in significant increases in macromolecular fraction estimated in AC and meniscus, obtained by two-pool MT modeling. T1, T1ρ and T2* biomarkers did not show consistent trends.

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