Abstract #1390

Effect of spin-lock field direction on chemical exchange spin-lock (CESL) and evaluate its feasibility of glycosaminoglycan (GAG) detection at 3.0T

Baiyan Jiang¹ and Weitian Chen¹

¹Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong

Chemical exchange spin-lock (CESL) is sensitive to fast exchange metabolites. CESL is performed across a range of resonance frequency offsets. At any frequency offset, either anti-parallel or parallel spin-lock directions can be used. However, different directions can affect the z-spectrum and the magnetization transfer ratio asymmetry analysis. We used simulations and in vivo experiments to demonstrate this effect and provided theoretical analysis. We also presented preliminary results of CESL for imaging of chemical exchange associated with glycosaminoglycan (GAG) in human knee at 3.0T.

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