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Abstract #1396

Multi-centric evaluation of stability of quantitative outcome measures in healthy calf muscles

Lara Schlaffke1,2,3, Alberto De Luca4, Louise Otto5, Robert Rehmann1, Marlena Rohm1, Jedrzej Burakiewicz3, Celine Baligand3, Jithsa Monte6, Chiel den Harder6, Aart Nederveen6, Hermien Kan3, and Martijn Froeling2

1Neurology, BG UK Bergmannsheil gGmbH, Bochum, Germany, 2Radiology, Universitiy Medical Center Utrecht, Utrecht, Netherlands, 3C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 4Image Science Institute, Universitiy Medical Center Utrecht, Utrecht, Netherlands, 5Brain Centre Rudolf Magnus, Neurology, Universitiy Medical Center Utrecht, Utrecht, Netherlands, 6Radiology, Academic Medical Center Amsterdam, Amsterdam, Netherlands

Clinical feasible, comparable muscle MR-techniques are crucial for monitoring disease progression and therapy in patients with neuromuscular diseases. We developed and evaluated a multi-modal quantitative MR protocol at 3T. Diffusion parameters, water T2 relaxation time and fat-fraction were measured and tested for temporal stability, multicenter reproducibility and covariate influence. Diffusion parameters stabilized after 15 minutes and were comparable between centers. Water T2 decreased 1ms within 1 hour. In dorsal muscles fat-fraction increased slightly, due to a decrease in muscle size. Temporal stability of quantitative parameters was shown and showed that T2 decrease needs to be considered when planning protocols.

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