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Abstract #1397

Exploring the Textural Differences between Diseased and Normal Muscle on T1 Weighted MRIs of the Mid-calf and Mid-thigh

Chang Tung Harold Yip1, Phua Hwee Tang2, and Kein Meng Wendy Liew3

1Duke-NUS Medical School, Singapore, Singapore, 2Department of Diagnoistic and Interventional Imaging, KK Women's And Children's Hospital, Singapore, Singapore, 3Paediatric Neurology, KK Women's and Children's Hospital, Singapore, Singapore

Textural analysis is a non-invasive objective method to characterize MRIs of subjects with muscular disorders. It has the potential to characterize muscle abnormalities that are not visible to the human eye. This allows the detection of muscle abnormalities earlier hence aiding early diagnosis and prognostication. This also allows textural analysis to be a potential quantitative outcome measure for clinical trials of drug treatments for muscular disorders. This study shows that the textural parameter entropy remains stable as age increases and can distinguish between diseased and normal muscle tissue.

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