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Abstract #1409

Assessment of perfusion-metabolism matching in exercising muscle from dynamic contrast-enhanced MRI and T2 mapping

Gwenael Layec1, christopher Conlin2, Jiawei Dong2, Stephen Decker3, Corey R Hart3, Nan Hu2, Mariya A Chadovich2, Michelle A Mueller2, Lillian Khor3, Christopher Hanrahan2, Vivian S Lee2, and Jeff L Zhang2

1VA Medical Center GRECC 182, 1D23A 500 Foothill Drive, University of Utah, Salt Lake City, UT, United States, 2Radiology, University of Utah, Salt Lake City, UT, United States, 3University of Utah, Salt Lake City, UT, United States

Using an MR approach combining DCE-MRI and T2 mapping, this study revealed that unlike PAD patients, muscle tissue perfusion was tightly correlated to exercise-induced changes in R2 in the lower leg muscles of healthy individuals. These findings suggest Q/Met mismatch following exercise in the skeletal muscle of PAD patients. The combination of DCE-MRI and T2 mapping opens a new avenue of research to investigate perfusion-metabolism heterogeneity in normal physiological conditions and muscle-related pathologies.

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