Abstract #1409

Assessment of perfusion-metabolism matching in exercising muscle from dynamic contrast-enhanced MRI and T2 mapping

Gwenael Layec¹, christopher Conlin², Jiawei Dong², Stephen Decker³, Corey R Hart³, Nan Hu², Mariya A Chadovich², Michelle A Mueller², Lillian Khor³, Christopher Hanrahan², Vivian S Lee², and Jeff L Zhang²

¹VA Medical Center GRECC 182, 1D23A 500 Foothill Drive, University of Utah, Salt Lake City, UT, United States, ²Radiology, University of Utah, Salt Lake City, UT, United States, ³University of Utah, Salt Lake City, UT, United States

Using an MR approach combining DCE-MRI and T2 mapping, this study revealed that unlike PAD patients, muscle tissue perfusion was tightly correlated to exercise-induced changes in R2 in the lower leg muscles of healthy individuals. These findings suggest Q/Met mismatch following exercise in the skeletal muscle of PAD patients. The combination of DCE-MRI and T2 mapping opens a new avenue of research to investigate perfusion-metabolism heterogeneity in normal physiological conditions and muscle-related pathologies.

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