Abstract #1410

Effects of PDE5A inhibition on skeletal muscle 1H2O T2 following an acute bout of downhill running and endurance training in dystrophic mice

Abhinandan Batra¹, Ravneet Vohra², Steve Chrzanowski¹, Donovan J Lott¹, Glenn A Walter¹, Krista Vandenborne¹, and Sean C Forbes¹

¹University of Florida, Gainesville, FL, United States, ²University of Washington, Seattle, WA, United States

This study examined the effects of phosphodiesterase 5A inhibition with sildenafil citrate on skeletal muscle ¹H₂O T₂ in dystrophic mice (mdx) following downhill running and during four weeks of low-intensity treadmill training. Skeletal muscle ¹H₂O T₂ was measured from spectra acquired with a single voxel ¹H-MRS STEAM sequence. Our findings showed less altered T₂ after downhill running with sildenafil citrate treatment indicating less muscle damage and improved running performance during endurance training. Collectively, the results support the use of sildenafil citrate when combined with acute and chronic bouts of exercise as a potential therapeutic intervention in muscular dystrophies.

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