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Abstract #1410

Effects of PDE5A inhibition on skeletal muscle 1H2O T2 following an acute bout of downhill running and endurance training in dystrophic mice

Abhinandan Batra1, Ravneet Vohra2, Steve Chrzanowski1, Donovan J Lott1, Glenn A Walter1, Krista Vandenborne1, and Sean C Forbes1

1University of Florida, Gainesville, FL, United States, 2University of Washington, Seattle, WA, United States

This study examined the effects of phosphodiesterase 5A inhibition with sildenafil citrate on skeletal muscle 1H2O T2 in dystrophic mice (mdx) following downhill running and during four weeks of low-intensity treadmill training. Skeletal muscle 1H2O T2 was measured from spectra acquired with a single voxel 1H-MRS STEAM sequence. Our findings showed less altered T2 after downhill running with sildenafil citrate treatment indicating less muscle damage and improved running performance during endurance training. Collectively, the results support the use of sildenafil citrate when combined with acute and chronic bouts of exercise as a potential therapeutic intervention in muscular dystrophies.

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