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Abstract #1427

MRI Methods for Exercise-based Perfusion Assessment of Diabetic Feet with Ulcers

Masoud A Edalati1, Mary K Hastings1, Zayed Mohamed1, David Muccigrosso1, Ran Li1, Michael J Mueller1, and Jie Zheng1

1Washington Univesity in St Louis, Saint Louis, MO, United States

The purpose of this study was to develop MRI methods for comprehensive evaluation of foot muscle perfusion and perfusion reserve in patients with diabetes and foot ulcers. Healthy controls and patients with diabetic foot ulcers were scanned with a non-contrast MRI protocol at rest and during a standardized foot flexion exercise. Ischemic regions around foot ulcers were clearly identified with quantitative perfusion data during the exercise.

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