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Abstract #1428

T1ρ, T2, and RAFF are Sensitive to Acute Ischemic Injury to the Femoral Head in a Piglet Model of Legg-Calvé-Perthes Disease

Casey P. Johnson1,2, Cathy S. Carlson3, Ferenc Toth3, Harry K. W. Kim4,5, and Jutta M. Ellermann1,2

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Radiology, University of Minnesota, Minneapolis, MN, United States, 3Veterinary Population Medicine, University of Minnesota, Saint Paul, MN, United States, 4Texas Scottish Rite Hospital for Children, Dallas, TX, United States, 5Orthopaedic Surgery, UT Southwestern Medical Center, Dallas, TX, United States

We demonstrate that quantitative T1ρ, T2, and RAFF relaxation time maps are highly sensitive to bone/marrow and cartilage changes within 48 hours following ischemic injury to the growing femoral head. This work has important implications for the diagnosis and treatment of diseases associated with avascular necrosis of bone and cartilage.

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