It is known that our collagen fiber alignment changes as we develop, reach maturity and then age: the crosslinking of collagen is considered one of the best biomarkers of aging. This study used magic angle imaging to visualise the collagen fiber changes between development and skeletal maturity in caprine knees. Immature tendons are less aligned during development, becoming more aligned as skeletal maturity is reached. This method has great potential to non-invasively improve our understanding of the development and degeneration of collagen rich structures.
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